Parkinson’s: The Funny Side

Paul Mayhew-Archer is a British writer (The Vicar of Dibley), producer, script editor and actor. He recently wrote a documentary called “Parkinson’s: The funny side”, which made us laugh. We thought you’d enjoy it too. It is available on iPlayer (search for Parkinson’s: The Funny Side), and can be viewed here along with other short films about Parkinson’s. ‘The Funny Side’ starts at 46 m 45 s.

In the documentary, Mayhew-Archer takes us to the University of Oxford’s Department of Anatomy and Physiology, where research is being undertaken to develop a phone app that can diagnose Parkinson’s using voice recordings.

He also tells us about exciting new research, funded by Parkinson’s UK, that’s identifying new targets for treatment. You can hear more about this research from the principle investigator, Professor Richard Wade Martins.

Quizzing On

Running out of quiz questions for your Zoom meet-ups with friends and family? Fear not, we’ve put together some entertaining quiz rounds to keep you going.

If you’re able, we’d love it if you made a donation to Parkinson’s UK, who are providing critical support throughout the Covid-19 crisis. If you’re not in a position to give at this time however, that’s fine too; quiz on!  

The Movie quiz

We dragged some children (kicking and screaming from their homeschooling lessons) into re-enacting some classic movie scenes for us. Can you name the movie titles?

Due to highly iconic instant-give-away theme tunes in some of the movies, some of the the clips – such as the first one – don’t have any sound. Others do however, so make sure you click “share computer sound” if you’re hosting the quiz via Zoom.

Question 1: Name that movie

Question 2: Also, name that movie

Question 3: You get the picture…

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Round one complete!
If you’re the quiz master, now is a good time to stop sharing your screen. The answers and bonus questions can be accessed via the Get The Answers button bellow.

The perils of being bipedal

Humans long ago made the evolutionary leap from walking on four legs to walking on two. As far as not-falling-over is concerned, this adaptation was a strange one. There’s a reason chairs tend to have, at the least, four legs.

Very few other mammals have gone the two-legged route: kangaroos spring to mind (sorry), but they benefit from a stabilising tail and clown-shoe-sized feet. Plus, they usually walk around as pentapeds (i.e. using all four legs and their tail). I’ve never tried to push a kangaroo over, but I’m guessing I’d be unsuccessful if I gave it a go. You, on the other hand, I could topple right over, if I timed it just right and gave you a vindictive enough of a shove.

To make matters worse, humans walk by balancing on one foot while swinging the other one forward. Paleoanthropologist John Napier describes walking as “a unique activity during which the body, step by step, teeters on the edge of catastrophe”. It’s a frankly ridiculous way to get around.

Movement scientists describe walking as controlled forward falling. We propel ourselves forwards – precariously – and then we swing out our other leg to avoid catastrophe. And then repeat, repeat, repeat, until we get to where we need to be. Just as in life, walking involves venturing towards an uncertain future in the hope that we arrive safely. Sometimes, however, we find ourselves arse-over-tit on the pavement.

There is, of course, a method to this human madness. Walking and standing on our hind legs opened up new opportunities for our ancestors. With our forelimbs freed up, they could use their hands for touch, exploration, tool-making and Googling how to make fires.

Modern-day humans continue to compensate for our ancestor’s sacrifice of stability in favour of constant access to skillful, handy hands. Staying upright in the outside world – with its kerbs, uneven paving stones and discarded banana skins – requires mind-boggling levels of neural computation to integrate multiple sensory inputs from the eyes, inner ear, and internal position sensors. All these inputs must then be transformed into accurate commands to our joints and muscles to maintain posture and allow purposeful locomotion.

Advancing age and neurodegenerative conditions such as Parkinson’s disease reduce the fidelity of these computations. It’s no surprise, then, that falls are common amongst older people and those with Parkinson’s disease. In fact, falls are the leading cause of death from injury in the over 65s. Non-fatal falls cost the NHS more than £2bn and four million bed days a year. Moreover, falls can be life-changing. They can make the difference between living well in your own home for the rest of your life, or losing your independence entirely.

The good news is that there are things older people can do to mitigate their risk of falling. Studies show that staying active and physically strong is highly effective in preventing falls. As is maintaining connection to social networks. It’s unfortunate that the current nationwide lockdown precludes older people from doing much of either.

For now, charities such as Age UK and Parkinson’s UK are providing continual online content and advice to help people stay active in their homes. Parkinson’s UK are also posting frequent home-based exercise videos to keep people active to their YouTube channel, and The Cure Parkinson’s Trust continue in their search for disease-modifying interventions.

To try to understand what people’s needs will be when life starts to return to normal (whatever that may be), my lab at Manchester Metropolitan University has recently launched a study on the impact that the lockdown is having on falls experienced by older people, and people with Parkinson’s disease.

To take part, please follow this link: Online study link

We’re all currently falling forward, but we’re swinging out a leg to prevent catastrophe.